Fertility & Treatments
605,479 babies were born in England and Wales in 20221
people in the UK are affected by infertility2
of known pregnancies end in miscarriage3
of couples will become pregnant within six months of trying4
individuals are effected by infertility across the globe5
miscarriages happen every single year, effecting over 25% of all pregnancies6
of women suffer from post-natal depression7
babies are born prematurely each year across the world8
1969
1978
Louise Brown β the world’s first baby conceived through in vitro fertilisation was born at Oldham Hospital – UK, after her mother received treatment from Edwards and Steptoe.8
1983
The birth of the first child conceived through egg donation.9
1984
A successful birth was achieved from a cryopreserved (aka frozen) embryo.10
1990
The first genetic screening to identify embryos without genetic defects for β¨at-risk couples.11
1991
The Human Fertilisation and Embryology Authority (HFEA) is formed β the world’s first IVF regulator.12
1992
Intracytoplasmic sperm injection (ICSI) was successfully used, resulting in four healthy babies (to four couples).11
1999
2005
Donor anonymity removed β people conceived through egg, sperm or embryo donation can find out who their parent(s’) donor was.12
2009
Same-sex and unmarried couples in the UK can both be legal parents without having to adopt under the HFE Act 2008.13
2010
Robert Edwards was awarded the Nobel Prize in Physiology/Medicine for the development of Human IVF Therapy.
2018
Louise Brown celebrates her 40th birthday.14
2022
The history of IVF
In vitro fertilisation (IVF) has greatly advanced since the birth of the first IVF baby in 1978.
- Office for National Statistics. Births in England and Wales: 2020. Available at: https://www.ons.gov.uk/peoplepopulationandcommunity/birthsdeathsandmarriages/livebirths/bulletins/birthsummarytablesenglandandwales/2022 [Last accessed: March 2022].
- Leaver RB. Male infertility: an overview of causes and treatment options. British Journal of Nursing 2016;25:S35-S40. Available at: https://www.magonlinelibrary.com/doi/full/10.12968/bjon.2016.25.18.S35 [Last accessed: March 2022].
- Brann M, Bute JJ. Communicating to promote informed decisions in the context of early pregnancy loss. Patient Education and Counseling 2017;100:2269-2274. Available at: https://www.sciencedirect.com/science/article/pii/S0738399117303622?via%3Dihub#bib0005 [Last accessed: March 2022].
- Taylor A. Extent of the problem. BMJ 2003;327:434. Available at: https://www.bmj.com/content/327/7412/434 [Last accessed: March 2022].
- WHO – Infertility Key Facts. Available at: https://www.who.int/news-room/fact-sheets/detail/infertility
- Fauser BC. Towards the global coverage of a unified registry of IVF outcomes. Reproductive BioMedicine Online 2019;38:133-137. Available at: https://pubmed.ncbi.nlm.nih.gov/30593441/ [Last accessed: March 2022].
- Brinsden PR. Thirty years of IVF: The legacy of Patrick Steptoe and Robert Edwards. Human Fertility 2009;12:137-143. Available at: https://www.tandfonline.com/doi/full/10.1080/14647270903176773 [Last accessed: March 2022].
- Brezina PR, Ning N, Mitchell E, Zacur HA, Baramki TA, Zhao Y. Recent Advances in Assisted Reproductive Technology. Current Obstetrics and Gynecology Reports 2012;1:166-173. Available at: https://link.springer.com/article/10.1007/s13669-012-0019-2 [Last accessed: March 2022].
- Monash IVF. Donor Eggs. Available at: https://monashivf.com/services/fertility-treatment-options/donor-eggs/ [Last accessed: March 2022].
- AP. First Baby Born of Frozen Embryo. New York Times 1984. Available at: https://www.nytimes.com/1984/04/11/us/first-baby-born-of-frozen-embryo.html [Last accessed: March 2022].
- Parikh FR, Athalye AS, Naik NJ, Naik DJ, Sanap RR, Madon PF. Preimplantation Genetic Testing: Its Evolution, Where Are We Today? Journal of Human Reproductive Science 2018;11:306-314. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333033/ [Last accessed: March 2022].
- Human Fertilisation and Embryology Authority. Celebrating 40 years of IVF. Available at: https://www.hfea.gov.uk/celebrating-40-years-of-ivf/ [Last accessed: March 2022].
- NGA Law. Parenthood after donor conception: female partners of birth mothers. Available at: https://www.ngalaw.co.uk/knowledge-centre/parenthood-after-donor-conception-female-partners-of-birth-mothers [Last accessed: March 2022].
- TIME. What It Was Like to Grow Up as the World’s First ‘Test-Tube Baby’. Available at: https://time.com/5344145/louise-brown-test-tube-baby/ [Last accessed: March 2022].
- ESHRE ART Fact Sheet. https://www.eshre.eu/Europe/Factsheets-and-infographics